![]() Experiment on tetrandrine as a synergist to bifonazole against Trichophyton mentagrophytes in vivo. In vivo study on tetrandrine as a synergist to econazole against Trichophyton mentagrophytes. Synergistic anti-candidal activity of tetrandrine on ketoconazole: an experimental study. Clinical investigation on the synergistic effect of tetrandrine on the antifungal activity of fluconazole for vulvovaginal candidiasis. ![]() Mechanism of action of tetrandrine, a natural inhibitor of Candida albicans drug efflux pumps. Zhang H, Gao A, Li F, Zhang G, Ho HI, Liao W. In vitro study on the synergistic effect and mechanism of tetrandrine to fluconazole against hyphal form of Candida albicans. Molecular mechanism of the synergy between tetrandrine and fluconazole against Candida albicans. Gao A, Zhang H, Mo H, Jiang H, Wang K, Chao H. In vivo study on tetrandrine as a synergist to fluconazole in murine model of vaginal candidiasis. Wang K, Zhang H, Jiang H, Shi J, GAO A, He H, et, al. In vitro study of the synergistic effect of tetrandrine and fluconazole against Candida albicans. The advantages of topical combination therapy in the treatment of inflammatory dermatomycoses. Antifungal combination treatment: a future perspective. Clin Diag Lab Immunol 1999 6:921–923.įohrer C, Fornecker L, Nivoix Y, Cornila C, Marinescu C, Herbrecht R. Successful treatment of fluconazole-resistant oropharyngeal candidiasis by a combination of fluconazole and terbinafine. Epidemiological trends in skin mycoses worldwide. TET synergistically enhanced the clinical efficacy of topical KZC cream in the treatment of dermatophytoses. ![]() No clinically significant changes were found in post-treatment routine blood, urine, or stool tests, ECG, or tests for liver and kidney function no serious adverse events occurred. No local skin redness or itching was observed during TET treatment. The rates of overall efficacy in the TET group were all zero. In the KCZ + TET group, all the clinical indices were significantly better than those in the KCZ group and TET group ( P<0.05). ![]() Among the patients with tinea pedis and/or tinea manuum after 4 weeks treatment, the overall cure rates in the KCZ + TET group and KCZ group were 75.00% vs. All clinical indices were significantly different between the combination therapy and only KCZ therapy groups ( P<0.05). 33.33% for combined treatment and KZC monotherapy, respectively, after 4 weeks. In the patients with tinea corporis and/or tinea cruris, the rates of overall cure (clinical cure plus mycologic clearance) were 81.25% vs. ResultsĬompared with KZC alone, combined use of KZC and TET showed lower MICs against clinical isolates of dermatophytes ( P<0.05 for all). The patients with tinea pedis and/or tinea manuum were treated for 4 weeks. Patients with tinea corporis and/or tinea cruris were treated for 2 weeks, separately. A randomized, double-blind trial was conducted among 97 patients with dermatophytoses who were assigned to 3 groups and received: treatment with combination of 2% KZC and 2% TET cream (KCZ + TET group), or only 2% KZC cream (KCZ group), or 2% TET cream (TET group). The minimum inhibitory concentrations (MICs) for KCZ and combined KCZ and TET were compared in vitro. To evaluate the synergistic effects of tetrandrine (TET) on the antifungal activity of topical ketoconazole (KCZ) in the treatment of dermatophytoses. ![]()
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